我们介绍了一种方法，例如针对3D点云的提案生成。现有技术通常直接在单个进料前进的步骤中回归建议，从而导致估计不准确。我们表明，这是一个关键的瓶颈，并提出了一种基于迭代双边滤波的方法。遵循双边滤波的精神，我们考虑了每个点的深度嵌入以及它们在3D空间中的位置。我们通过合成实验表明，在为给定的兴趣点生成实例建议时，我们的方法会带来巨大的改进。我们进一步验证了我们在挑战性扫描基准测试中的方法，从而在自上而下的方法的子类别中实现了最佳实例分割性能。

我们为3D点云提出了一种自我监督的胶囊架构。我们通过置换等级的注意力计算对象的胶囊分解，并通过用对随机旋转对象的对进行自我监督处理。我们的主要思想是将注意力掩码汇总为语义关键点，并使用这些来监督满足胶囊不变性/设备的分解。这不仅能够培训语义一致的分解，而且还允许我们学习一个能够以对客观的推理的规范化操作。培训我们的神经网络，我们既不需要分类标签也没有手动对齐训练数据集。然而，通过以自我监督方式学习以对象形式的表示，我们的方法在3D点云重建，规范化和无监督的分类上表现出最先进的。

Multimodal deep learning has been used to predict clinical endpoints and diagnoses from clinical routine data. However, these models suffer from scaling issues: they have to learn pairwise interactions between each piece of information in each data type, thereby escalating model complexity beyond manageable scales. This has so far precluded a widespread use of multimodal deep learning. Here, we present a new technical approach of "learnable synergies", in which the model only selects relevant interactions between data modalities and keeps an "internal memory" of relevant data. Our approach is easily scalable and naturally adapts to multimodal data inputs from clinical routine. We demonstrate this approach on three large multimodal datasets from radiology and ophthalmology and show that it outperforms state-of-the-art models in clinically relevant diagnosis tasks. Our new approach is transferable and will allow the application of multimodal deep learning to a broad set of clinically relevant problems.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

The success of Deep Learning applications critically depends on the quality and scale of the underlying training data. Generative adversarial networks (GANs) can generate arbitrary large datasets, but diversity and fidelity are limited, which has recently been addressed by denoising diffusion probabilistic models (DDPMs) whose superiority has been demonstrated on natural images. In this study, we propose Medfusion, a conditional latent DDPM for medical images. We compare our DDPM-based model against GAN-based models, which constitute the current state-of-the-art in the medical domain. Medfusion was trained and compared with (i) StyleGan-3 on n=101,442 images from the AIROGS challenge dataset to generate fundoscopies with and without glaucoma, (ii) ProGAN on n=191,027 from the CheXpert dataset to generate radiographs with and without cardiomegaly and (iii) wGAN on n=19,557 images from the CRCMS dataset to generate histopathological images with and without microsatellite stability. In the AIROGS, CRMCS, and CheXpert datasets, Medfusion achieved lower (=better) FID than the GANs (11.63 versus 20.43, 30.03 versus 49.26, and 17.28 versus 84.31). Also, fidelity (precision) and diversity (recall) were higher (=better) for Medfusion in all three datasets. Our study shows that DDPM are a superior alternative to GANs for image synthesis in the medical domain.

We present a noisy channel generative model of two sequences, for example text and speech, which enables uncovering the association between the two modalities when limited paired data is available. To address the intractability of the exact model under a realistic data setup, we propose a variational inference approximation. To train this variational model with categorical data, we propose a KL encoder loss approach which has connections to the wake-sleep algorithm. Identifying the joint or conditional distributions by only observing unpaired samples from the marginals is only possible under certain conditions in the data distribution and we discuss under what type of conditional independence assumptions that might be achieved, which guides the architecture designs. Experimental results show that even tiny amount of paired data (5 minutes) is sufficient to learn to relate the two modalities (graphemes and phonemes here) when a massive amount of unpaired data is available, paving the path to adopting this principled approach for all seq2seq models in low data resource regimes.

Pronoun resolution is a challenging subset of an essential field in natural language processing called coreference resolution. Coreference resolution is about finding all entities in the text that refers to the same real-world entity. This paper presents a hybrid model combining multiple rulebased sieves with a machine-learning sieve for pronouns. For this purpose, seven high-precision rule-based sieves are designed for the Persian language. Then, a random forest classifier links pronouns to the previous partial clusters. The presented method demonstrates exemplary performance using pipeline design and combining the advantages of machine learning and rulebased methods. This method has solved some challenges in end-to-end models. In this paper, the authors develop a Persian coreference corpus called Mehr in the form of 400 documents. This corpus fixes some weaknesses of the previous corpora in the Persian language. Finally, the efficiency of the presented system compared to the earlier model in Persian is reported by evaluating the proposed method on the Mehr and Uppsala test sets.

Coreference resolution (CR) is one of the most challenging areas of natural language processing. This task seeks to identify all textual references to the same real-world entity. Research in this field is divided into coreference resolution and anaphora resolution. Due to its application in textual comprehension and its utility in other tasks such as information extraction systems, document summarization, and machine translation, this field has attracted considerable interest. Consequently, it has a significant effect on the quality of these systems. This article reviews the existing corpora and evaluation metrics in this field. Then, an overview of the coreference algorithms, from rule-based methods to the latest deep learning techniques, is provided. Finally, coreference resolution and pronoun resolution systems in Persian are investigated.

Recent advances in computer vision have shown promising results in image generation. Diffusion probabilistic models in particular have generated realistic images from textual input, as demonstrated by DALL-E 2, Imagen and Stable Diffusion. However, their use in medicine, where image data typically comprises three-dimensional volumes, has not been systematically evaluated. Synthetic images may play a crucial role in privacy preserving artificial intelligence and can also be used to augment small datasets. Here we show that diffusion probabilistic models can synthesize high quality medical imaging data, which we show for Magnetic Resonance Images (MRI) and Computed Tomography (CT) images. We provide quantitative measurements of their performance through a reader study with two medical experts who rated the quality of the synthesized images in three categories: Realistic image appearance, anatomical correctness and consistency between slices. Furthermore, we demonstrate that synthetic images can be used in a self-supervised pre-training and improve the performance of breast segmentation models when data is scarce (dice score 0.91 vs. 0.95 without vs. with synthetic data).

Existing metrics for evaluating the quality of automatically generated questions such as BLEU, ROUGE, BERTScore, and BLEURT compare the reference and predicted questions, providing a high score when there is a considerable lexical overlap or semantic similarity between the candidate and the reference questions. This approach has two major shortcomings. First, we need expensive human-provided reference questions. Second, it penalises valid questions that may not have high lexical or semantic similarity to the reference questions. In this paper, we propose a new metric, RQUGE, based on the answerability of the candidate question given the context. The metric consists of a question-answering and a span scorer module, in which we use pre-trained models from the existing literature, and therefore, our metric can be used without further training. We show that RQUGE has a higher correlation with human judgment without relying on the reference question. RQUGE is shown to be significantly more robust to several adversarial corruptions. Additionally, we illustrate that we can significantly improve the performance of QA models on out-of-domain datasets by fine-tuning on the synthetic data generated by a question generation model and re-ranked by RQUGE.